Sex-associated differences in the immune response against fetal major histocompatibility antigens. II. Association of the female IgG1 with H-2K-encoded alloantigens.


Alloantibodies against the H-2b haplotype were produced in C3HeB female and male parental mice in response to transplantation of F1 fetal tissue (bones). In testing IgG1 and IgG2 antibodies by means of the FACS II we found striking sex-associated differences in the isotypes produced: female mice produced much more IgG1 than male mice, although they produced… (More)


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