• Biology, Medicine
  • Published in Nature Reviews Genetics 2012
  • DOI:10.1038/nrg3161

Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity

@article{Matson2012SexAT,
  title={Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity},
  author={Clinton K. Matson and David A Zarkower},
  journal={Nature Reviews Genetics},
  year={2012},
  volume={13},
  pages={163-174}
}
Most animals reproduce sexually, but the genetic and molecular mechanisms that determine the eventual sex of each embryo vary remarkably. DM domain genes, which are related to the insect gene doublesex, are integral to sexual development and its evolution in many metazoans. Recent studies of DM domain genes reveal mechanisms by which new sexual dimorphisms have evolved in invertebrates and show that one gene, Dmrt1, was central to multiple evolutionary transitions between sex-determining… CONTINUE READING

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