Sex and strain differences in ethanol drinking: effects of gonadectomy.

@article{Cailhol2001SexAS,
  title={Sex and strain differences in ethanol drinking: effects of gonadectomy.},
  author={St{\'e}phanie Cailhol and Pierre Morm{\'e}de},
  journal={Alcoholism, clinical and experimental research},
  year={2001},
  volume={25 4},
  pages={
          594-9
        }
}
BACKGROUND Alcohol drinking behavior in rats is known to be sexually dimorphic and strain-dependent. METHODS To test whether the gonadal steroid milieu exerts activational effects on ethanol intake and can modulate individual sensitivity toward alcohol use and misuse, we examined the effects of gonadectomy on oral self-administration (OSA) of ethanol in male and female rats from different strains. After castration, animals were given continuous free choice between water and ethanol solutions… CONTINUE READING

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