Sex and gender in lung health and disease: more than just Xs and Ys

@article{Weatherald2021SexAG,
  title={Sex and gender in lung health and disease: more than just Xs and Ys},
  author={Jason Weatherald and Renata L. Riha and Marc Humbert},
  journal={European Respiratory Review},
  year={2021},
  volume={30}
}
Every nucleated human cell carries sex chromosomes and every person has a gender. These terms “sex” and “gender” are often used interchangeably and incorrectly in the scientific literature, but they mean different things: sex is a biological attribute associated with physical and physiological features determined by chromosomes, hormones, anatomy and gene expression; whereas gender is a sociocultural construct based on expressions of identity, behaviours and social roles [1]. Thus, sex and… 
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Clinical and Immunological Markers of Pulmonary Impairment Among People With HIV in India
TLDR
Female sex, higher concentrations ofIL-6 and D-dimer, and lower concentrations of IL-10 were associated with pulmonary impairment in adult PWH receiving antiretroviral therapy in India.

References

SHOWING 1-9 OF 9 REFERENCES
Sex and gender in respiratory physiology
TLDR
The number of transsexual people is increasing and they represent new challenges for clinicians, due to the anatomical and physiological changes that they undergo, and medicine for women is therefore less evidence-based than that being applied to men.
Just breathe: a review of sex and gender in chronic lung disease
TLDR
The sex- and gender-based differences in key chronic lung diseases are summarized and the clinical and research implications for stakeholders are outlined.
Sex and gender in asthma
TLDR
The role of sex hormones, genetics and epigenetics, and their interactions with the environment in the clinical manifestations and therapeutic response of asthma are reviewed.
The evolving landscape of sex-based differences in lung cancer: a distinct disease in women
TLDR
Lung cancer may increasingly be viewed as a distinct disease in women, with implications for screening and treatment, and sex-based differences in outcomes and side effects of systemic therapy should be captured.
Sex, gender and the pulmonary physiology of exercise
TLDR
How the pulmonary system's response to exercise is impacted by both sex and gender in healthy humans across the lifespan is detailed.
Sex and gender in interstitial lung diseases
TLDR
The interplay between biological sex and behavioural gender explains a significant proportion of the variability seen in ILD, and for a more individualised, patient-centred medicine, sex and gender influences in disease need to be accounted for.
Sex and gender in pulmonary arterial hypertension
TLDR
Pulmonary arterial hypertension affects women more than men, although women have a better prognosis, and oestrogens might be the key to explain these gender differences.
How to integrate sex and gender into research
    Gender Medicine: The Groundbreaking New Science of Gender- and Sex-Related Diagnosis and Treatment
    • London, Overlook Books,
    • 2021