Sex and estrous cycle-dependent rapid protein kinase signaling actions of estrogen in distal colonic cells.

Abstract

Previous studies from our laboratory demonstrated that 17beta-estradiol (E2) rapidly inhibits Cl(-) secretion in rat and human distal colonic epithelium. The inhibition has been shown to occur via targeting of a basolateral K(+) channel identified as the KCNQ1 (KvLQT1) channel. E2 indirectly modulates the channel activity via a cascade of second messengers… (More)
DOI: 10.1016/j.steroids.2008.01.021

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