Sex and estrogen receptor expression influence opioid peptide levels in the mouse hippocampal mossy fiber pathway.

@article{Kempen2013SexAE,
  title={Sex and estrogen receptor expression influence opioid peptide levels in the mouse hippocampal mossy fiber pathway.},
  author={Tracey A. Van Kempen and Sana Kahlid and Andreina D Gonzalez and Joanna L Spencer-Segal and Mumeko C. Tsuda and Sonoko Ogawa and Bruce S. McEwen and Elizabeth M. Waters and Teresa A Milner},
  journal={Neuroscience letters},
  year={2013},
  volume={552},
  pages={66-70}
}
The opioid peptides, dynorphin (DYN) and enkephalin (L-ENK) are contained in the hippocampal mossy fiber pathway where they modulate synaptic plasticity. In rats, the levels of DYN and L-ENK immunoreactivity (-ir) are increased when estrogen levels are elevated (Torres-Reveron et al., 2008, 2009). Here, we used quantitative immunocytochemistry to examine whether opioid levels are similarly regulated in wildtype (WT) mice over the estrous cycle, and how these compared to males. Moreover, using… CONTINUE READING