Sex and environmental influences on the size and ultrastructure of the rat corpus callosum

@article{Juraska1988SexAE,
  title={Sex and environmental influences on the size and ultrastructure of the rat corpus callosum},
  author={Janice M Juraska and John R. Kopcik},
  journal={Brain Research},
  year={1988},
  volume={450},
  pages={1-8}
}
A contested report of sex differences in the size of the splenium of the corpus callosum in humans prompted the present examination of the corpus callosum in the rat. We have previously found that sex differences can vary with the rearing environment. Consequently, male and female rats were raised from weaning to 55 days of age in either a complex or an isolated environment. There were no sex differences in the size of the corpus callosum in sagittal cross section in these rats; however, rats… 
Gender differences in the rat corpus callosum: An ultrastructure study
TLDR
The findings of the present study indicated region‐specific differences in the myelinated, unmyelinated or the ratio of myelination/total axons in the CC between male and female rats.
The effects of prenatal stress on the size of the corpus callosum
TLDR
Results showed a sex difference for area, perimeter, and length of the corpus callosum, with males having larger values on all three measures, but when body weight was taken into consideration, these sex differences disappeared.
Sex differences in the corpus callosum of the living human being
TLDR
While there was no conclusive evidence of sexual dimorphism in the area of the corpus callosum or its subdivisions, there was significant sex differences in shape, which could, in part, underlie gender-related differences in behavior and neuropsychological function.
Commissural size in neonatal rats: Effects of sex and prenatal alcohol exposure
TLDR
Results indicate that sex differences in the size of the corpus callosum are present at birth, and the effects of prenatal alcohol exposure on male, but not female, offspring suggest that this alcohol‐related birth defect is hormonally mediated.
The size of the splenium of the rat corpus callosum: influence of hormones, sex ratio, and neonatal cryoanesthesia.
TLDR
Testosterone injections in females were found to increase the size of the splenium relative to oil-injected females and duration of cryoanesthesia negatively correlated with splenial area in males and females.
Sex differences in the distribution of axon types within the genu of the rat corpus callosum
TLDR
A significant sex difference in the ratio of unmyelinated to myelinated axons was shown in adult male and female rats in the anterior portion, the genu, with females having a larger proportion of unMyelinated fibers.
A re-examination of sex differences in axon density and number in the splenium of the rat corpus callosum
TLDR
The present study revisits the issue of sex differences in axon number in the splenium of the adult rat corpus callosum and investigates the topographical organization of axons in thesplenium.
Differential rearing affects corpus callosum size and cognitive function of rhesus monkeys
TLDR
Rearing environment was associated with sustained differences in cross-hemispheric projections, white matter volume and cognitive performance, and cognitive deficits exhibited by the NURSERY animals were significantly correlated with the alterations found in the CC.
Sex and species differences in mouse and rat forebrain commissures depend on the method of adjusting for brain size
TLDR
Sex differences in the forebrain commissures of B6D2F2 hybrid mice and Sprague-Dawley rats were examined and no species or sex differences were apparent after adjustments were made for brain size with either the regression or allometric methods.
Sex differences in the development of axon number in the splenium of the rat corpus callosum from postnatal day 15 through 60.
  • J. Kim, J. Juraska
  • Biology, Medicine
    Brain research. Developmental brain research
  • 1997
TLDR
In the rat splenium, males appear to attain the adult number of axons earlier than females, and results indicate that there is a sex difference in the timing of axon withdrawal in the rat Splenium, with axon withdrawals continuing in females after it has ceased in males.
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