Sex- and dose-dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats.

@article{MilesiHall2005SexAD,
  title={Sex- and dose-dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats.},
  author={Alessandra Milesi-Hall{\'e} and Howard P. Hendrickson and Elizabeth M Laurenzana and William Brooks Gentry and S Michael Owens},
  journal={Toxicology and applied pharmacology},
  year={2005},
  volume={209 3},
  pages={203-13}
}
These studies investigated how (+)-methamphetamine (METH) dose and rat sex affect the pharmacological response to METH in Sprague-Dawley rats. The first set of experiments determined the pharmacokinetics of METH and its pharmacologically active metabolite (+)-amphetamine (AMP) in male and female Sprague-Dawley rats after 1.0 and 3.0 mg/kg METH doses. The results showed significant sex-dependent changes in METH pharmacokinetics, and females formed significantly lower amounts of AMP. While the… CONTINUE READING

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