Sex- and Diet-Specific Changes of Imprinted Gene Expression and DNA Methylation in Mouse Placenta under a High-Fat Diet

@inproceedings{GallouKabani2010SexAD,
  title={Sex- and Diet-Specific Changes of Imprinted Gene Expression and DNA Methylation in Mouse Placenta under a High-Fat Diet},
  author={Catherine Gallou-Kabani and Anne Gabory and J{\"o}rg Tost and Mohsen. Karimi and Sylvain Mayeur and Jean Claude Lesage and Elsa Boudadi and M. Gross and Julien Taurelle and Alexandre Vig{\'e} and Christophe Breton and Brigitte M Reusens and Claude A Remacle and Didier Vieau and Tomas J. Ekstr{\"o}m and Jean-Philippe Jais and Claudine Junien},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Changes in imprinted gene dosage in the placenta may compromise the prenatal control of nutritional resources. Indeed monoallelic behaviour and sensitivity to changes in regional epigenetic state render imprinted genes both vulnerable and adaptable. METHODS AND FINDINGS We investigated whether a high-fat diet (HFD) during pregnancy modified the expression of imprinted genes and local and global DNA methylation patterns in the placenta. Pregnant mice were fed a HFD or a control diet… CONTINUE READING
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