Sex Steroids and Cardiovascular Outcomes in Transgender Individuals: A Systematic Review and Meta‐Analysis

@article{Maraka2017SexSA,
  title={Sex Steroids and Cardiovascular Outcomes in Transgender Individuals: A Systematic Review and Meta‐Analysis},
  author={Spyridoula Maraka and Naykky M Singh Ospina and Ren{\'e} Rodr{\'i}guez‐Guti{\'e}rrez and Caroline J. Davidge-Pitts and Todd B. Nippoldt and Larry J. Prokop and Hassan Murad},
  journal={The Journal of Clinical Endocrinology \& Metabolism},
  year={2017},
  volume={102},
  pages={3914–3923}
}
Background: Transgender individuals receive cross‐sex hormonal therapy to induce desired secondary sexual characteristics despite limited data regarding its effects on cardiovascular health. Methods: A comprehensive search of several databases up to 7 April 2015 was conducted for studies evaluating the effect of sex steroid use on lipids, myocardial infarction, stroke, venous thromboembolism (VTE), and mortality in transgender individuals. Pairs of reviewers selected and appraised the studies… 
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Studies describing a higher risk for cardiometabolic and thromboembolic morbidity and/or mortality in transgender women (but not transgender men) mainly covered data on transgender women using the now obsolete ethinyl estradiol and are no longer valid.

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...

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