Sex-Steroid Hormone Manipulation Reduces Brain Response to Reward

@article{Macoveanu2016SexSteroidHM,
  title={Sex-Steroid Hormone Manipulation Reduces Brain Response to Reward},
  author={Julian Macoveanu and Susanne Henningsson and Anja Pinborg and Peter Hobolt Jensen and Gitte Moos Knudsen and Vibe G. Frokjaer and Hartwig R. Siebner},
  journal={Neuropsychopharmacology},
  year={2016},
  volume={41},
  pages={1057-1065}
}
Mood disorders are twice as frequent in women than in men. Risk mechanisms for major depression include adverse responses to acute changes in sex-steroid hormone levels, eg, postpartum in women. Such adverse responses may involve an altered processing of rewards. Here, we examine how women’s vulnerability for mood disorders is linked to sex-steroid dynamics by investigating the effects of a pharmacologically induced fluctuation in ovarian sex steroids on the brain response to monetary rewards… CONTINUE READING
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