Sex Specification and Heterogeneity of Primordial Germ Cells in Mice.

  title={Sex Specification and Heterogeneity of Primordial Germ Cells in Mice.},
  author={Akihiko Sakashita and Yukiko Kawabata and Yuko Jincho and Shiun Tajima and Soichiro Kumamoto and Hisato Kobayashi and Yasuhisa Matsui and Tomohiro Kono},
  journal={PloS one},
  volume={10 12},
In mice, primordial germ cells migrate into the genital ridges by embryonic day 13.5 (E13.5), where they are then subjected to a sex-specific fate with female and male primordial germ cells undergoing mitotic arrest and meiosis, respectively. However, the sex-specific basis of primordial germ cell differentiation is poorly understood. The aim of this study was to investigate the sex-specific features of mouse primordial germ cells. We performed RNA-sequencing (seq) of E13.5 female and male… CONTINUE READING
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