Sex-Specific Modulation of Gene Expression Networks in Murine Hypothalamus

  title={Sex-Specific Modulation of Gene Expression Networks in Murine Hypothalamus},
  author={Khyobeni Mozhui and Lu Lu and William E. Armstrong and Robert W. Williams},
  booktitle={Front. Neurosci.},
The hypothalamus contains nuclei and cell populations that are critical in reproduction and that differ significantly between the sexes in structure and function. To examine the molecular and genetic basis for these differences, we quantified gene expression in the hypothalamus of 39 pairs of adult male and female mice belonging to the BXD strains. This experimental design enabled us to define hypothalamic gene coexpression networks and provided robust estimates of absolute expression… CONTINUE READING

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