Sex-Specific Effects of Stress on Oxytocin Neurons Correspond With Responses to Intranasal Oxytocin

@article{Steinman2016SexSpecificEO,
  title={Sex-Specific Effects of Stress on Oxytocin Neurons Correspond With Responses to Intranasal Oxytocin},
  author={Michael Q. Steinman and Natalia Duque-Wilckens and Gian D. Greenberg and Rebecca Hao and Brian C. Trainor},
  journal={Biological Psychiatry},
  year={2016},
  volume={80},
  pages={406-414}
}
BACKGROUND Oxytocin (OT) is considered to be a stress-buffering hormone, dampening the physiologic effects of stress. However, OT can also be anxiogenic. We examined acute and long-lasting effects of social defeat on OT neurons in male and female California mice. METHODS We used immunohistochemistry for OT and c-fos cells to examine OT neuron activity immediately after defeat (n = 6-9) and 2 weeks (n = 6-9) and 10 weeks (n = 4-5) later. We quantified Oxt messenger RNA with quantitative… CONTINUE READING
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Sex differences in social interaction behavior following social defeat stress in the monogamous California mouse (Peromyscus californicus)

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