Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity
@article{Markle2013SexDI, title={Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity}, author={Janet G. Markle and Daniel N. Frank and Steven Mortin-Toth and Charles E. Robertson and Leah M. Feazel and Ulrike E. Rolle-Kampczyk and Martin von Bergen and Kathy D. McCoy and Andrew J. Macpherson and Jayne S. Danska}, journal={Science}, year={2013}, volume={339}, pages={1084 - 1088} }
Mighty Male Microbes Both genetic and environmental factors contribute to an individual's susceptibility to autoimmune disease, but the specific environmental influences are not well characterized. Markle et al. (p. 1084, published online 17 January; see the Perspective by Flak et al.) explored how microbial factors, in particular the gut microbiota, influence susceptibility to type 1 diabetes in mice. In the non-obese diabetic (NOD) mouse model of type 1 diabetes, female mice are significantly…
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