Sex Differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE).

@article{Jiang2014SexDI,
  title={Sex Differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE).},
  author={Wei Jiang and Gary S. Gilkeson},
  journal={Journal of immunotherapy applications},
  year={2014},
  volume={1},
  pages={1}
}
It has been shown that TLR7 and TLR9 signaling play a role in SLE pathogenesis. Our recent study revealed that estrogen receptor α knockout mice have impaired inflammatory responses to TLR3, TLR4, TLR7 and TLR9 ligand stimulation in DCs, B cells and whole spleen cells. These findings indicate that estrogen receptor mediated signaling may impact universal TLR responsiveness. Whether estrogen has a direct or indirect effect on TLR responsiveness by immune cells is not clear. There is evidence of… CONTINUE READING
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