Sex Differences in Postischemic Cardiac Dysfunction and Norepinephrine Overflow in Rat Heart: The Role of Estrogen Against Myocardial Ischemia–reperfusion Damage Via an NO-mediated Mechanism

@article{Fukumoto2012SexDI,
  title={Sex Differences in Postischemic Cardiac Dysfunction and Norepinephrine Overflow in Rat Heart: The Role of Estrogen Against Myocardial Ischemia–reperfusion Damage Via an NO-mediated Mechanism},
  author={Taiki Fukumoto and Naoto Yamashita and Masashi Tawa and Mamoru Ohkita and Yasuo Matsumura},
  journal={Journal of Cardiovascular Pharmacology},
  year={2012},
  volume={60},
  pages={269–275}
}
Abstract: The purpose of this study is to elucidate the relationship between sex difference and norepinephrine (NE) release in the pathogenesis of myocardial ischemia/reperfusion (I/R) injury. Isolated male and female rat hearts were subjected to 40-minute global ischemia followed by 30-minute reperfusion. Compared with male hearts, I/R-induced cardiac dysfunction, such as decreased left ventricular developed pressure and dP/dtmax and increased left ventricular end diastolic pressure, was… Expand
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