Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress.

@article{Hodes2015SexDI,
  title={Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress.},
  author={Georgia E Hodes and Madeline L. Pfau and Immanuel Purushothaman and H. Francisca Ahn and Sam A Golden and Daniel J Christoffel and Jane K Magida and Anna Brancato and Aki Takahashi and Meghan E Flanigan and Caroline M{\'e}nard and Hossein Aleyasin and Ja Wook Koo and Zachary S. Lorsch and Jian Feng and M. G. Sahab A. A. R. Heshmati and Minghui Wang and Gustavo Turecki and Rachel L. Neve and Bin Zhang and Li Shen and Eric J Nestler and Scott J Russo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 50},
  pages={16362-76}
}
UNLABELLED Depression and anxiety disorders are more prevalent in females, but the majority of research in animal models, the first step in finding new treatments, has focused predominantly on males. Here we report that exposure to subchronic variable stress (SCVS) induces depression-associated behaviors in female mice, whereas males are resilient as they do not develop these behavioral abnormalities. In concert with these different behavioral responses, transcriptional analysis of nucleus… CONTINUE READING
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