Sex Differences in Mutation Rate in Higher Primates Estimated from AMG Intron Sequences

@article{Huang1997SexDI,
  title={Sex Differences in Mutation Rate in Higher Primates Estimated from AMG Intron Sequences},
  author={Wei Huang and Benny H.-J. Chang and Xun Gu and David Hewett-Emmett and W.-H. Li},
  journal={Journal of Molecular Evolution},
  year={1997},
  volume={44},
  pages={463-465}
}
To study sex differences in mutation rate in primates, we sequenced the third introns of the AMGX and AMGY genes from humans, orangutans, and squirrel monkeys and estimated that the male-to-female ratio of mutation rate is α= 5.14 with the 95% confidence interval (2.42, 16.6). Combining this data set and the data sets from ZFX/ZFY and SMCX/SMCY introns, we obtained an estimate of α= 5.06 with the 95% confidence interval reduced to (3.24, 8.79). The α value is significantly higher in higher… CONTINUE READING