Sex Differences in GABAA Signaling in the Periaqueductal Gray Induced by Persistent Inflammation.

@article{Tonsfeldt2016SexDI,
  title={Sex Differences in GABAA Signaling in the Periaqueductal Gray Induced by Persistent Inflammation.},
  author={Karen J Tonsfeldt and Katherine L. Suchland and Kathleen A. Beeson and Janet D Lowe and Minghua Li and Susan L Ingram},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2016},
  volume={36 5},
  pages={1669-81}
}
UNLABELLED The ventrolateral periaqueductal gray (vlPAG) is a key structure in the descending pain modulatory circuit. Activation of the circuit occurs via disinhibition of GABAergic inputs onto vlPAG output neurons. In these studies, we tested the hypothesis that GABAergic inhibition is increased during persistent inflammation, dampening activation of the descending circuit from the vlPAG. Our results indicate that persistent inflammation induced by Complete Freund's adjuvant (CFA) modulates… CONTINUE READING

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The ventrolateral periaqueductal gray ( vlPAG ) is a key structure in the descending pain modulatory circuit .
The ventrolateral periaqueductal gray ( vlPAG ) is a key structure in the descending pain modulatory circuit .
The ventrolateral periaqueductal gray ( vlPAG ) is a key structure in the descending pain modulatory circuit .
The ventrolateral periaqueductal gray ( vlPAG ) is a key structure in the descending pain modulatory circuit .
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