Sex Determining Region Y-Box 2 (SOX2) Is a Potential Cell-Lineage Gene Highly Expressed in the Pathogenesis of Squamous Cell Carcinomas of the Lung

@inproceedings{Yuan2010SexDR,
  title={Sex Determining Region Y-Box 2 (SOX2) Is a Potential Cell-Lineage Gene Highly Expressed in the Pathogenesis of Squamous Cell Carcinomas of the Lung},
  author={Ping Yuan and Humam Kadara and Carmen Behrens and Ximing Tang and Denise Woods and Luisa M. Solis and Jiaoti Huang and Monica Spinola and Wenli Dong and Guosheng Yin and Junya Fujimoto and Edward Kim and Yang Xie and Luc Girard and C{\'e}sar A. Moran and Waun Ki Hong and John D. Minna and Ignacio Wistuba},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Non-small cell lung cancer (NSCLC) represents the majority (85%) of lung cancers and is comprised mainly of adenocarcinomas and squamous cell carcinomas (SCCs). The sequential pathogenesis of lung adenocarcinomas and SCCs occurs through dissimilar phases as the former tumors typically arise in the lung periphery whereas the latter normally arise near the central airway. METHODOLOGY/PRINCIPAL FINDINGS We assessed the expression of SOX2, an embryonic stem cell transcriptional factor… CONTINUE READING