Sex Chromosome Specialization and Degeneration in Mammals

@article{Graves2006SexCS,
  title={Sex Chromosome Specialization and Degeneration in Mammals},
  author={Jennifer A. Marshall Graves},
  journal={Cell},
  year={2006},
  volume={124},
  pages={901-914}
}
  • J. Graves
  • Published 10 March 2006
  • Medicine, Biology
  • Cell
Sex chromosomes--particularly the human Y--have been a source of fascination for decades because of their unique transmission patterns and their peculiar cytology. The outpouring of genomic data confirms that their atypical structure and gene composition break the rules of genome organization, function, and evolution. The X has been shaped by dosage differences to have a biased gene content and to be subject to inactivation in females. The Y chromosome seems to be a product of a perverse… 
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The evolution of mammalian orthologs is examined to determine if the selective forces that led to the degeneration of the Y chromosome are unique in the genome, and the results of the study suggest these forces are not exclusive to the Y chromosomes.
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