Sevoflurane versus propofol for electroconvulsive therapy: effects on seizure parameters, anesthesia recovery, and the bispectral index.

Abstract

BACKGROUND/AIM In this prospective randomized cross-over study we compare the effects of sevoflurane versus propofol for electroconvulsive therapy (ECT) anesthesia. MATERIALS AND METHODS Twenty four patients (ASA I-III, 18-65 years old) receiving ECT three times per week were included. Anesthesia was induced with either propofol (0.75 mg/kg iv) or 5% sevoflurane in 100% oxygen. Consecutive ECT sessions followed a 2 × 2 crossover design and a 2-day washout period until the 10th ECT. Intravenous succinylcholine (1 mg/kg) was administered while bispectral index (BIS) values were ≤60%. RESULTS Electromyogram and electroencephalogram seizure duration, postictal suppression index, BIS values, mean arterial blood pressure (MAP), heart rate, times to start of spontaneous respiration, eye opening, understanding verbal commands, and side effects were compared. No differences were found between the regimens for seizure activity and recovery. At the end of ECT, MAP was higher with sevoflurane. Although BIS values were higher after sevoflurane, no differences between the regimens were found in terms of the need of muscle relaxants and in hypnosis levels. CONCLUSION Sevoflurane (5%) may be an effective alternative to propofol for induction of anesthesia for ECT.

DOI: 10.3906/sag-1502-110

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Cite this paper

@article{Pekel2016SevofluraneVP, title={Sevoflurane versus propofol for electroconvulsive therapy: effects on seizure parameters, anesthesia recovery, and the bispectral index.}, author={Melekşah Pekel and Nadide Aysun Postaci and Ismail Aytac and Derya Karasu and H{\"{u}seyin Keleş and {\"{O}zlem Şen and Bayazit Dikmen and Erol G{\"{o}ka}, journal={Turkish journal of medical sciences}, year={2016}, volume={46 3}, pages={756-63} }