Sevoflurane preconditioning attenuates myocardial ischemia/reperfusion injury via caveolin-3-dependent cyclooxygenase-2 inhibition.

@article{Zhao2013SevofluranePA,
  title={Sevoflurane preconditioning attenuates myocardial ischemia/reperfusion injury via caveolin-3-dependent cyclooxygenase-2 inhibition.},
  author={Jianli Zhao and Feng Wang and Yanqing Zhang and Liyuan Jiao and Wayne Bond Lau and Li-li Wang and Baojiang Liu and E. Mei Gao and Walter J Koch and Xin-liang Ma and Yajing Wang},
  journal={Circulation},
  year={2013},
  volume={128 11 Suppl 1},
  pages={S121-9}
}
BACKGROUND The inhaled anesthetic sevoflurane has been demonstrated to protect against myocardial ischemia/reperfusion (MI/R) injury via mechanisms involving AMP-activated protein kinase (AMPK) and caveolin-3 (Cav-3). However, the relative contributions of AMPK and Cav-3 to sevoflurane preconditioning (SF-PreCon)-mediated cardioprotection and their precise underlying mechanisms of action remain incompletely understood. METHODS AND RESULTS SF-PreCon (consisting of 3 cycles of 15-minute… CONTINUE READING

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