Sevoflurane postconditioning protects isolated rat hearts against ischemia-reperfusion injury.

@article{Yao2010SevofluranePP,
  title={Sevoflurane postconditioning protects isolated rat hearts against ischemia-reperfusion injury.},
  author={Yun-tai Yao and Neng-xin Fang and Chun-xia Shi and Li-huan Li},
  journal={Chinese medical journal},
  year={2010},
  volume={123 10},
  pages={1320-8}
}
BACKGROUND Studies suggested that anesthetics administered upon the early reperfusion or "anesthetic postconditioning" could protect post-ischemic hearts against myocardial ischemia reperfusion injury (MIRI). However, the mechanism responsible for such protection was not well-elucidated. We investigated the cardioprotection induced by sevoflurane postconditioning (SpostC) in rat hearts in vitro, and the respective role of phosphatidylinositol-3-kinase (PI3K), extracellular signal-regulated… CONTINUE READING

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