Sevoflurane inhibits embryonic stem cell self-renewal and subsequent neural differentiation by modulating the let-7a-Lin28 signaling pathway

  title={Sevoflurane inhibits embryonic stem cell self-renewal and subsequent neural differentiation by modulating the let-7a-Lin28 signaling pathway},
  author={Xiuwen Yi and Yirong Cai and N. Zhang and Q. Wang and W. Li},
  journal={Cell and Tissue Research},
  • Xiuwen Yi, Yirong Cai, +2 authors W. Li
  • Published 2016
  • Biology, Medicine
  • Cell and Tissue Research
  • The commonly used inhalational anesthetic, sevoflurane, can cause toxicity to the central nervous system of the developing fetus. Lin28 has been reported to regulate let-7a, thereby modulating embryo development, neurodegeneration, and even neuron-related tumorigenesis. We demonstrate that pregnant mice receiving sevoflurane treatment during the early stage of pregnancy give birth to fewer offspring presenting a lower birth weight. We have also treated mouse embryonic stem cells (mESCs) with… CONTINUE READING
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