Sevoflurane inhalation at sedative concentrations provides endothelial protection against ischemia-reperfusion injury in humans.

@article{Lucchinetti2007SevofluraneIA,
  title={Sevoflurane inhalation at sedative concentrations provides endothelial protection against ischemia-reperfusion injury in humans.},
  author={Eliana Lucchinetti and Sandro Ambrosio and Jos{\'e} Aguirre and Patrick Herrmann and Luc H{\"a}rter and Marius Keel and Thomas Meier and Michael Zaugg},
  journal={Anesthesiology},
  year={2007},
  volume={106 2},
  pages={262-8}
}
BACKGROUND Endothelial cells can be protected against cytokine-induced toxicity by volatile anesthetics. The authors tested whether inhalation of sevoflurane at subanesthetic concentrations provides protection against postocclusive endothelial dysfunction induced by ischemia-reperfusion injury of the forearm in humans. METHODS Five healthy male volunteers were enrolled in this study with crossover design. Each subject was randomly exposed to 15 min of forearm ischemia in the presence or… CONTINUE READING
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