Sevoflurane exposure generates superoxide but leads to decreased superoxide during ischemia and reperfusion in isolated hearts.

@article{Kevin2003SevofluraneEG,
  title={Sevoflurane exposure generates superoxide but leads to decreased superoxide during ischemia and reperfusion in isolated hearts.},
  author={Leo G. Kevin and Enis Novalija and Matthias L Riess and Amadou K. S. Camara and Samhita Rhodes and David F. Stowe},
  journal={Anesthesia and analgesia},
  year={2003},
  volume={96 4},
  pages={949-55, table of contents}
}
UNLABELLED Reactive oxygen species (ROS) are largely responsible for cardiac injury consequent to ischemia and reperfusion, but, paradoxically, there is evidence suggesting that anesthetics induce preconditioning (APC) by generating ROS. We hypothesized that sevoflurane generates the ROS superoxide (O(2)(.-)), that APC attenuates O(2)(.-) formation during ischemia, and that this attenuation is reversed by bracketing APC with the O(2)(.-) scavenger manganese (III) tetrakis (4-benzoic acid… CONTINUE READING

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