Sevoflurane depresses neurons in the medial parabrachial nucleus by potentiating postsynaptic GABAA receptors and background potassium channels

@article{Xu2020SevofluraneDN,
  title={Sevoflurane depresses neurons in the medial parabrachial nucleus by potentiating postsynaptic GABAA receptors and background potassium channels},
  author={Wei Xu and Lu Wang and Xiang-Shan Yuan and Tian-xiao Wang and Wen-Xian Li and Wei-Min Qu and Zong-yuan Hong and Zhi-Li Huang},
  journal={Neuropharmacology},
  year={2020},
  volume={181}
}
1 Citations
Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction
TLDR
The diagnosis of postoperative cognitive dysfunction is reviewed, animal models of POCD are introduced in clinical research, the possible mechanisms of sevoflurane-induced P OCD are analyzed, and advances in treatment for this condition are summarized.

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Evidence is provided that sevoflurane causes immobility by a mechanism distinct from the actions of the intravenous anesthetic propofol, and glycine and GABAA receptors are the most important molecular targets mediating depressant effects of sev ofluranes in the spinal cord.
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