Sevoflurane ameliorates gas exchange and attenuates lung damage in experimental lipopolysaccharide-induced lung injury.

@article{Voigtsberger2009SevofluraneAG,
  title={Sevoflurane ameliorates gas exchange and attenuates lung damage in experimental lipopolysaccharide-induced lung injury.},
  author={Stefanie Voigtsberger and Robert A. Lachmann and Anik C Leutert and Martin Schl{\"a}pfer and Christa Booy and L. Nieto Reyes and Martin Urner and Julia Schild and Ralph C. Schimmer and Beatrice Beck-Schimmer},
  journal={Anesthesiology},
  year={2009},
  volume={111 6},
  pages={1238-48}
}
BACKGROUND Acute lung injury is a common complication in critically ill patients. Several studies suggest that volatile anesthetics have immunomodulating effects. The aim of the current study was to assess possible postconditioning with sevoflurane in an in vivo model of endotoxin-induced lung injury. METHODS Rats were anesthetized, tracheotomized, and mechanically ventilated. Lipopolysaccharide (saline as control) was administered intratracheally. Upon injury after 2 h of propofol anesthesia… CONTINUE READING

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A randomized controlled trial on pharmacological preconditioning in liver surgery using a volatile anesthetic

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