Sevoflurane ameliorates doxorubicin-induced myocardial injury by affecting the phosphorylation states of proteins in PI3K/Akt/mTOR signaling pathway.

@article{Wu2017SevofluraneAD,
  title={Sevoflurane ameliorates doxorubicin-induced myocardial injury by affecting the phosphorylation states of proteins in PI3K/Akt/mTOR signaling pathway.},
  author={Yini Wu and Jianping Wang and Xiaoyan Yu and Dongli Li and Xin Han and Lihua Fan},
  journal={Cardiology journal},
  year={2017},
  volume={24 4},
  pages={
          409-418
        }
}
BACKGROUND The effect of sevoflurane on the doxorubicin-induced myocardial injury was explored by investigating the phosphorylation states of proteins in phosphatidylinositol 3-kinase (PI3K)/Akt/mam-malian target of rapamycin (mTOR) signaling pathway. METHODS Myocardial injury rat models were induced by doxorubicin and evenly assigned into five groups according to different treatment: Doxorubicin group (DG, 200-μL saline solution), sevoflurane group (SevG, inhaled with 2.4% sevoflurane for 2… CONTINUE READING
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