Sevoflurane Anesthesia Improves Cognitive Performance in Mice, but Does Not Influence In Vitro Long-Term Potentation in Hippocampus CA1 Stratum Radiatum

@inproceedings{Haseneder2013SevofluraneAI,
  title={Sevoflurane Anesthesia Improves Cognitive Performance in Mice, but Does Not Influence In Vitro Long-Term Potentation in Hippocampus CA1 Stratum Radiatum},
  author={Rainer Haseneder and Laura K. Starker and Jasmin Berkmann and Kristine Kellermann and Bettina Jungwirth and Manfred Blobner and Matthias Eder and Eberhard F. Kochs and Gerhard Rammes},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND Whether the occurrence of postoperative cognitive dysfunction is a result of the effects of surgery or anesthesia is under debate. In this study, we investigated the impact of sevoflurane anesthesia on cognitive performance and cellular mechanisms involved in learning and memory. METHODS Male C57Bl6/J mice (4-5 months) were exposed to one minimum alveolar concentration sevoflurane for two hours. After 24 h, cognitive performance of mice was assessed using the modified hole board… CONTINUE READING

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