Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins.

@article{Malhotra2001SevilleOJ,
  title={Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins.},
  author={Shivani Malhotra and David G Bailey and Mary Paine and Paul B Watkins},
  journal={Clinical pharmacology and therapeutics},
  year={2001},
  volume={69 1},
  pages={14-23}
}
OBJECTIVE Our objective was to determine whether Seville orange juice produces a grapefruit juice-like interaction with felodipine and whether bergamottin, 6',7'-dihydroxybergamottin, or other furocoumarins are involved. METHODS In a randomized three-way crossover design, 10 volunteers received a felodipine 10-mg extended-release tablet with 240 mL of Seville orange juice, dilute grapefruit juice (that contained equivalent total molar concentrations of bergamottin plus 6',7… CONTINUE READING

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