Seville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults.

@article{Penzak2001SevilleO,
  title={Seville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults.},
  author={Scott R. Penzak and Michael W. Jann and Julie A. Cold and Yuen Yi Hon and Hiral D. Desai and Bill Gurley},
  journal={Journal of clinical pharmacology},
  year={2001},
  volume={41 10},
  pages={1059-63}
}
The Seville orange extract Citrus aurantium contains m-synephrine (phenylephrine) and octopamine; it causes cardiac disturbances in animals and is used by humans for weight loss. Juice from the orange (Seville orange juice [SOJ]) is used to "knock out" intestinal cytochrome P450 (CYP) 3A4 in bioavailability studies. The purpose of this study was to determine synephrine and octopamine concentrations in SOJ and SOJ's cardiovascular effects in normotensive humans. Subjects consumed 8 ounces of SOJ… CONTINUE READING

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