Severity of pancreatitis-associated gut barrier dysfunction is reduced following treatment with the PAF inhibitor lexipafant.

@article{Leveau2005SeverityOP,
  title={Severity of pancreatitis-associated gut barrier dysfunction is reduced following treatment with the PAF inhibitor lexipafant.},
  author={Per Leveau and Xiangdong Wang and Zhengwu Sun and Anna B{\"o}rjesson and Ellen Andersson and Roland I Andersson},
  journal={Biochemical pharmacology},
  year={2005},
  volume={69 9},
  pages={1325-31}
}
The aim of the present study was to investigate the potential effect of treatment with a platelet-activating factor (PAF) antagonist, lexipafant (BB-882), on gut endothelial and epithelial barrier dysfunction and leukocyte recruitment in rats with acute pancreatitis. Severe acute pancreatitis was induced by the intraductal administration of 5% sodium… CONTINUE READING