Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo.

@article{Kanamori1996SeverityOH,
  title={Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo.},
  author={Keiko Kanamori and Brian D. Ross and Justin Chung and Elbert Kuo},
  journal={Journal of neurochemistry},
  year={1996},
  volume={67 4},
  pages={1584-94}
}
Correlation among in vivo glutamine synthetase (GS) activity, brain ammonia and glutamine concentrations, and severity of encephalopathy was examined in hyperammonemic rats to obtain quantitative information on the capacity of GS to control these metabolites implicated in the etiology of hepatic encephalopathy. Awake rats were observed for neurobehavioral impairments after ammonium acetate infusion to attain a steady-state blood ammonia concentration of 0.9 (group A) or 1.3 mumol/g (group B… CONTINUE READING
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