Severity of experimental brain injury on lactate and free fatty acid accumulation and Evans blue extravasation in the rat cortex and hippocampus.

@article{Dhillon1999SeverityOE,
  title={Severity of experimental brain injury on lactate and free fatty acid accumulation and Evans blue extravasation in the rat cortex and hippocampus.},
  author={Harbhajan S. Dhillon and Heidi M. Carman and Dexing Zhang and Stephen William Scheff and Mani Ram Prasad},
  journal={Journal of neurotrauma},
  year={1999},
  volume={16 6},
  pages={455-69}
}
Lactate and free fatty acids (FFAs) were extracted from the cortices and hippocampi of rats subjected to sham operation, or mild (1.25 atm) or moderate (2.0 atm) fluid percussion (FP) injury, and their total tissue concentrations were measured. The elevation of lactate in the injured left cortex (IC) and ipsilateral hippocampus (IH) was significantly greater in the moderate-injury than in the mild-injury group at most test times between 5 min and 48 h after injury. Levels of total FFAs were… CONTINUE READING