Severity of cardiac conduction involvement and arrhythmias in myotonic dystrophy type 1 correlates with age and CTG repeat length.

@article{Groh2002SeverityOC,
  title={Severity of cardiac conduction involvement and arrhythmias in myotonic dystrophy type 1 correlates with age and CTG repeat length.},
  author={William J. Groh and Miriam Rachel Lowe and Douglas Peter Zipes},
  journal={Journal of cardiovascular electrophysiology},
  year={2002},
  volume={13 5},
  pages={444-8}
}
INTRODUCTION Cardiac myopathy manifesting with conduction disturbances and arrhythmias is common in the neurologic disease myotonic dystrophy. We studied whether the severity of cardiac involvement in myotonic dystrophy correlates with the severity of the genetic abnormality cytosine-thymine-guanine (CTG) repeat expansion. METHODS AND RESULTS History, physical examination, ECG evaluation, and genetic testing were performed in patients with a clinical diagnosis of myotonic dystrophy. In 342 of… CONTINUE READING

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