Severity and phenotype of bullous pemphigoid relate to autoantibody profile against the NH2- and COOH-terminal regions of the BP180 ectodomain.

@article{Hofmann2002SeverityAP,
  title={Severity and phenotype of bullous pemphigoid relate to autoantibody profile against the NH2- and COOH-terminal regions of the BP180 ectodomain.},
  author={SilkeC Hofmann and Sybille Thoma-Uszynski and Thomas K. Hunziker and Philippe Bernard and Corinna Koebnick and Angelika Stauber and Gerold Schuler and Luca Borradori and Michael Hertl},
  journal={The Journal of investigative dermatology},
  year={2002},
  volume={119 5},
  pages={1065-73}
}
Bullous pemphigoid, the most common autoimmune subepidermal bullous disorder, is associated with autoantibodies targeting antigenic sites clustered within the extracellular domain of BP180. To investigate epitope and subclass specificity of autoantibodies in bullous pemphigoid, we developed an enzyme-linked immunosorbent assay utilizing baculovirus-expressed recombinant forms of the NH2- and COOH-terminal regions of the extracellular domain of BP180 and examined sera obtained from patients with… CONTINUE READING
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