Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE).

@article{Norman1997SeverityAM,
  title={Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE).},
  author={James G. Norman and Jun Yang and George Fink and Gay L. Carter and Grace Ku and Woody Denham and David Livingston},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={1997},
  volume={17 2},
  pages={113-8}
}
Interleukin-1 beta (IL-1 beta) is produced in large amounts during acute pancreatitis and is believed to play a role in disease progression. Because secretion of IL-1 beta is dependent on intracellular processing of pro-IL-1 beta by IL-1 converting enzyme (ICE), we aimed to determine the efficacy of a novel ICE inactivator (VE-13045) in inhibiting secretion of active IL-1 beta in vivo and if the loss of ICE activity would affect the severity and mortality of experimental pancreatitis. Severe… CONTINUE READING
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