Severity-Dependent Long-Term Spatial Learning-Memory Impairment in a Mouse Model of Traumatic Brain Injury

@article{An2016SeverityDependentLS,
  title={Severity-Dependent Long-Term Spatial Learning-Memory Impairment in a Mouse Model of Traumatic Brain Injury},
  author={Chengrui An and Xiaoyan Jiang and Hongjian Pu and Dandan Hong and Wenting Zhang and Xiaoming Hu and Yanqin Gao},
  journal={Translational Stroke Research},
  year={2016},
  volume={7},
  pages={512-520}
}
Traumatic brain injury (TBI) is a major cause of death and disability in young adults. Long-term mental disability often occurs in patients suffering moderate and severe TBI while not as frequent in the victims of mild TBI. To explore the potential mechanism underlying this severity-dependent cognitive deficit, we subjected C57/BL6 mice to different severities of controlled cortical impact (CCI) and assessed their learning-memory functions. The mice subjected to moderate and severe TBI… CONTINUE READING
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