Severing all ties between mother and daughter: cell separation in budding yeast

@article{Yeong2005SeveringAT,
  title={Severing all ties between mother and daughter: cell separation in budding yeast},
  author={Foong May Yeong},
  journal={Molecular Microbiology},
  year={2005},
  volume={55}
}
  • F. M. Yeong
  • Published 1 March 2005
  • Biology
  • Molecular Microbiology
At the end of nuclear division in the budding yeast, acto‐myosin ring contraction and cytokinesis occur between mother and daughter cells. This is followed by cell separation, after which mother and daughter cells go their separate ways. While cell separation may be the last event that takes place between the two cells, it is nonetheless under tight regulation which ensures that both cells are viable upon separation. It is becoming increasingly clear that the components of the cell separation… 
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56 Citations

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Investigating molecular crowding during cell division in budding yeast with FRET
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References

SHOWING 1-10 OF 60 REFERENCES
MEN, destruction and separation: mechanistic links between mitotic exit and cytokinesis in budding yeast.
TLDR
It is proposed that the requirement of MEN components for cytokinesis, their translocation to the mother-daughter neck and triggering of this translocation by inactivation of the mitotic kinase may be the three crucial elements that render initiation of cytokineis dependent on mitotic exit.
Septation and cytokinesis in fungi.
The septation apparatus, an autonomous system in budding yeast.
TLDR
The septation apparatus, composed of septins, contractile ring, and the chitin synthase II system, can function at ectopic locations autonomously and independently of cell division, and that it can recruit the other elements necessary for the formation of secondary septa.
Comparative Analysis of Cytokinesis in Budding Yeast, Fission Yeast and Animal Cells
Involvement of an Actomyosin Contractile Ring in Saccharomyces cerevisiae Cytokinesis
TLDR
The contractile actomyosin ring is not essential for cytokinesis in S. cerevisiae, and in its absence, cytokineses can still be completed by a process that appears to require septin function and to be facilitated by F-actin.
Inactivation of mitotic kinase triggers translocation of MEN components to mother-daughter neck in yeast.
TLDR
It is shown that Dbf2 and Dbf20 functions are necessary for the execution of cytokinesis, and the requirement of kinase inactivation for translocation of MEN components to the division site thus provides a mechanism that renders mitotic exit a prerequisite for cytokineis.
The budding yeast Cdc15 localizes to the spindle pole body in a cell-cycle-dependent manner.
TLDR
The results presented here suggest that the transient cell-cycle-dependent localization of Cdc15 to the SPB plays a role in the regulation of the latest stages of the cell cycle.
Timing is everything: regulation of mitotic exit and cytokinesis by the MEN and SIN.
Sequential Assembly of Myosin II, an IQGAP-like Protein, and Filamentous Actin to a Ring Structure Involved in Budding Yeast Cytokinesis
TLDR
Results indicate that cytokinesis in budding yeast is likely to involve an actomyosin-based contractile ring, and Cyk1p plays a role in the recruitment of actin filaments, perhaps through a filament-binding activity similar to that demonstrated for mammalian IQGAPs.
The Yeast Cell Wall and Septum as Paradigms of Cell Growth and Morphogenesis*
TLDR
Because of the versatility of budding yeast for biochemical and genetic studies, the most comprehensive body of work on fungal cell walls has been carried out with this organism, and this review will deal specifically with Saccharomyces cerevisiae.
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