Severing all ties between mother and daughter: cell separation in budding yeast

@article{Yeong2005SeveringAT,
  title={Severing all ties between mother and daughter: cell separation in budding yeast},
  author={Foong May Yeong},
  journal={Molecular Microbiology},
  year={2005},
  volume={55}
}
  • F. M. Yeong
  • Published 1 March 2005
  • Biology
  • Molecular Microbiology
At the end of nuclear division in the budding yeast, acto‐myosin ring contraction and cytokinesis occur between mother and daughter cells. This is followed by cell separation, after which mother and daughter cells go their separate ways. While cell separation may be the last event that takes place between the two cells, it is nonetheless under tight regulation which ensures that both cells are viable upon separation. It is becoming increasingly clear that the components of the cell separation… 

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References

SHOWING 1-10 OF 60 REFERENCES

MEN, destruction and separation: mechanistic links between mitotic exit and cytokinesis in budding yeast.

It is proposed that the requirement of MEN components for cytokinesis, their translocation to the mother-daughter neck and triggering of this translocation by inactivation of the mitotic kinase may be the three crucial elements that render initiation of cytokineis dependent on mitotic exit.

The septation apparatus, an autonomous system in budding yeast.

The septation apparatus, composed of septins, contractile ring, and the chitin synthase II system, can function at ectopic locations autonomously and independently of cell division, and that it can recruit the other elements necessary for the formation of secondary septa.

Involvement of an Actomyosin Contractile Ring in Saccharomyces cerevisiae Cytokinesis

The contractile actomyosin ring is not essential for cytokinesis in S. cerevisiae, and in its absence, cytokineses can still be completed by a process that appears to require septin function and to be facilitated by F-actin.

Inactivation of mitotic kinase triggers translocation of MEN components to mother-daughter neck in yeast.

It is shown that Dbf2 and Dbf20 functions are necessary for the execution of cytokinesis, and the requirement of kinase inactivation for translocation of MEN components to the division site thus provides a mechanism that renders mitotic exit a prerequisite for cytokineis.

The budding yeast Cdc15 localizes to the spindle pole body in a cell-cycle-dependent manner.

The results presented here suggest that the transient cell-cycle-dependent localization of Cdc15 to the SPB plays a role in the regulation of the latest stages of the cell cycle.

Sequential Assembly of Myosin II, an IQGAP-like Protein, and Filamentous Actin to a Ring Structure Involved in Budding Yeast Cytokinesis

Results indicate that cytokinesis in budding yeast is likely to involve an actomyosin-based contractile ring, and Cyk1p plays a role in the recruitment of actin filaments, perhaps through a filament-binding activity similar to that demonstrated for mammalian IQGAPs.

The Yeast Cell Wall and Septum as Paradigms of Cell Growth and Morphogenesis*

Because of the versatility of budding yeast for biochemical and genetic studies, the most comprehensive body of work on fungal cell walls has been carried out with this organism, and this review will deal specifically with Saccharomyces cerevisiae.

A Septin-based Hierarchy of Proteins Required for Localized Deposition of Chitin in the Saccharomyces cerevisiae Cell Wall

Results suggest that the normal localization of chitin synthase III activity is achieved by assembly of a complex in which Chs3p is linked to the septins via Chs4p and Bni4p.

The Cbk1p Pathway Is Important for Polarized Cell Growth and Cell Separation in Saccharomyces cerevisiae

The results suggest that Cbk1p and Hym1p function to regulate two distinct cell morphogenesis pathways: an ACE2-independent pathway that is required for efficient apical growth and mating projection formation and anACE2-dependent pathways that is necessary for efficient cell separation following cytokinesis.
...