Severe vincristine toxicity in combination with itraconazole.


We report two patients with acute lymphoblastic leukaemia (ALL) who were entered into the current MRC adult ALL trial (UKALL XII) in whom unusually severe vincristine induced neurotoxicity developed. This appeared to be the result of an interaction with itraconazole suspension.


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@article{Gillies1998SevereVT, title={Severe vincristine toxicity in combination with itraconazole.}, author={James Gillies and K A Hung and Edward J. Fitzsimons and Richard L Soutar}, journal={Clinical and laboratory haematology}, year={1998}, volume={20 2}, pages={123-4} }