Severe sepsis and septic shock: the role of gram-negative bacteremia.

@article{Munford2006SevereSA,
  title={Severe sepsis and septic shock: the role of gram-negative bacteremia.},
  author={Robert S. Munford},
  journal={Annual review of pathology},
  year={2006},
  volume={1},
  pages={
          467-96
        }
}
Abstract Although Gram-negative bacteria have often been implicated in the pathogenesis of severe sepsis and septic shock, how they trigger these often lethal syndromes is uncertain. In particular, the role played by blood-borne bacteria is controversial. This review considers two alternatives. In the first, circulating Gram-negative bacteria induce toxic reactions directly within the vasculature; in the second, the major inflammatory stimulus occurs in local extravascular sites of infection… CONTINUE READING

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