Severe sensitivity loss in an influenza A molecular assay due to antigenic drift variants during the 2014/15 influenza season.

@article{Overmeire2016SevereSL,
  title={Severe sensitivity loss in an influenza A molecular assay due to antigenic drift variants during the 2014/15 influenza season.},
  author={Yarah Overmeire and Elke Vanlaere and Anneleen Hombrouck and Hans De Beenhouwer and Guus F M Simons and Antoinette A. T. P. Brink and Anne-Marie Van den Abeele and Charlotte J Verfaillie and J W G Van Acker},
  journal={Diagnostic microbiology and infectious disease},
  year={2016},
  volume={85 1},
  pages={42-6}
}
The 2014-2015 influenza season in Belgium was dominated by the circulation of 2 influenza A(H3N2) subgroups: 3C.2a and 3C.3b. Analysis of 166 nasopharyngeal aspirates, collected in patients with respiratory illness at the start of the epidemic season, showed a decreased sensitivity for the detection of influenza A(H3N2)/3C.2a using a commercially available multiplex assay. Gene sequencing of the matrix protein showed a point mutation (C163T) leading to a mismatch with the assay probes. 
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