Severe retinopathy of prematurity associated with FZD4 mutations.

  title={Severe retinopathy of prematurity associated with FZD4 mutations.},
  author={Anna L. Ells and Duane L. Guernsey and Karin Wallace and Binyou Zheng and Michael J. Vincer and Alexander J. Allen and April Ingram and Orlando P Dasilva and Lee Siebert and Thomas G Sheidow and J. -M. Beis and Johane M. Robitaille},
  journal={Ophthalmic genetics},
  volume={31 1},
PURPOSE To determine whether mutations in the FZD4 gene are a risk factor for developing severe ROP. METHODS Three Canadian tertiary care centers recruited premature infants prospectively and retrospectively, and assigned affectation status based on the maximum degree of severity of ROP recorded in both eyes. Mutation screening of the FZD4 gene was… CONTINUE READING