Severe recurrent bacterial infections associated with defective adherence and chemotaxis in two patients with neutrophils deficient in a cell-associated glycoprotein.

@article{Bowen1982SevereRB,
  title={Severe recurrent bacterial infections associated with defective adherence and chemotaxis in two patients with neutrophils deficient in a cell-associated glycoprotein.},
  author={Thomas J Bowen and Hans D. Ochs and Leonard C. Altman and Thomas R. Price and Dennis E. Van Epps and David L. Brautigan and R E Rosin and William D. Perkins and Bernard M. Babior and Seymour J. Klebanoff and Ralph Wedgwood},
  journal={The Journal of pediatrics},
  year={1982},
  volume={101 6},
  pages={
          932-40
        }
}
We studied two patients with delayed umbilical cord detachment, recurrent bacterial infections, inability to form pus, rapidly progressive periodontitis, and persistent leukocytosis. The phagocytes of both patients were strikingly abnormal in their ability to adhere to surfaces. The adherence of polymorphonuclear leukocytes to endotoxin-coated glass coverslips, glass beads, or nylon wool was markedly reduced. Scanning electron microscopy of the few adherent polymorphonuclear leukocytes from… CONTINUE READING