Severe protein C deficiency predicts early death in severe sepsis.

  title={Severe protein C deficiency predicts early death in severe sepsis.},
  author={William L. Macias and David R. Nelson},
  journal={Critical care medicine},
  volume={32 5 Suppl},
OBJECTIVE To explore the relationship between measures of baseline disease severity and survival time in patients with severe sepsis. DATA SOURCE A retrospective evaluation of the placebo group from a large placebo-controlled phase III clinical trial (PROWESS) comprising a total of 840 patients with severe sepsis from 164 medical centers. DATA EXTRACTION AND SYNTHESIS Data collected included baseline demographics and disease severity measurements, baseline protein C and interleukin-6 levels… CONTINUE READING

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