Severe oxidatively damaged DNA after cisplatin treatment of cancer patients.

@article{Siomek2006SevereOD,
  title={Severe oxidatively damaged DNA after cisplatin treatment of cancer patients.},
  author={Agnieszka Siomek and Jerzy Tujakowski and Daniel Gackowski and Rafal Rozalski and Marek Foksiński and Tomasz Dziaman and Krzysztof Roszkowski and Ryszard Olinski},
  journal={International journal of cancer},
  year={2006},
  volume={119 9},
  pages={
          2228-30
        }
}
  • Agnieszka Siomek, Jerzy Tujakowski, +5 authors Ryszard Olinski
  • Published in
    International journal of…
    2006
  • Medicine
  • There is growing evidence suggesting that cytotoxic activity of cisplatin is closely associated with increased generation of reactive oxygen species (ROS). Therefore, this study was undertaken to examine oxidative DNA damage, which arises as a result of chemotherapy with cisplatin. Using HPLC prepurification/isotope dilution GC/MS methodology, we examined the amount of 8-oxoGua and 8-oxodG excreted into urine in cancer patients (n = 66) who received chemotherapy with cisplatin. One day after… CONTINUE READING

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