Severe ototoxicity following carboplatin-containing conditioning regimen for autologous marrow transplantation for neuroblastoma

@article{Parsons1998SevereOF,
  title={Severe ototoxicity following carboplatin-containing conditioning regimen for autologous marrow transplantation for neuroblastoma},
  author={S Parsons and MW Neault and L E Lehmann and L. Patrick Brennan and C E Eickhoff and CS Kretschmar and LR Diller},
  journal={Bone Marrow Transplantation},
  year={1998},
  volume={22},
  pages={669-674}
}
Children with neuroblastoma receiving high-dose carboplatin as part of their conditioning regimen for autologous marrow transplantation have a high incidence of speech frequency hearing loss. We evaluated hearing loss in 11 children with advanced stage neuroblastoma who underwent autologous marrow transplantation, following a conditioning regimen containing high-dose carboplatin (2 g/m2, total dose). Audiometric evaluations were obtained at diagnosis, prior to and following transplant. Exposure… CONTINUE READING

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